I don't mind hunting the fence, but I have a few rules I follow to ensure that when I do put my riflescope reticle on a buck everything goes in my favor. First, I use a large caliber. I'm fond of .30 caliber rifles and live and die by the .300 Winchester magnum packaged in my TC Pro Hunter (www.tcarms.com). It's not the only .30 that works, but it is hard hitting whether hitting home at 100 yards or 300.
My second rule of thumb is to use quality ammunition with a high grade bullet. This season I'm using Hornady's Superformance ammunition (www.hornady.com) topped with the GMX bullet in 150-grain weight. It's the weight that shoots best from my .300 and my early tests echo Hornady's claims of nearly total weight retention and maximum expansion whether hitting close or far. So far this season I've used them on pronghorn, deer and elk. Nothing made it over the fence.