The truth is, there is no sure-fire guarantee, no silver bullet, no magic cartridge that can anchor a deer or even a coyote every time. Hit the central nervous system and bullet energy hardly matters. Down it goes. Punch through the lungs, heart, or liver, and sometimes an animal collapses instantly. But more often it stands, walks, or runs for as many as 10 seconds before falling blood pressure makes it faint. This is what you see when a heart-shot buck runs, starts wobbling, falls, tries to rise, falls again, and expires. It’s classic oxygen deprivation. Sometimes heart-lung hit animals die instantly from so-called hydrostatic shock. Evidence suggests this is most likely from the bullet’s impact causing blood vessels to rupture in the animal’s brain.